the effect of letrozole in induction of ovulation in clomiphene resistant patients
نویسندگان
چکیده
background: in patients with anovulatory infertility the first choice of treatment for ovulation induction is an antiestrogen, most commonly clomiphene citrate (cc). however, 20-25% of the women are resistant to cc and do not ovulate perhaps due to antiestrogenic mechanism of the cc action, which involves long-lasting estrogen receptor (er) depletion. objective: the objective of the study was to mimic the action of cc without depletion of ers by the administration of an aromatase inhibitor letrozole in a selected group of poly cystic ovary (pco) patients who demonstrated failure to ovulate after treatment with cc. materials and methods: 20 patients with anovulation due to polycystic ovary syndrome (pcos), who had previously inadequately responded to cc were selected for study. the aromatase inhibitor letrozole was administered orally in a dose of 2.5 mg on days 3-7 of the menstrual cycle. then, occurrence of ovulation, endometrial thickness, and pregnancy rates were determined. result(s): only one patient had one dominant follicle (1.8 cm diameter) on day 14 of the cycle (estradiol = 200 pg/ml). iui was done; however, no pregnancy took place. in the remaining cases, several sonographies were done between days 9 to 15 of the cycle; however, all cycles were cancelled due to absence of a dominant follicle (>1.4 cm). conclusion(s): our study did not confirm the favorable effect of letrozole for induction of ovulation in patients with clomiphene resistant pco. article
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عنوان ژورنال:
international journal of reproductive biomedicineجلد ۲، شماره ۲، صفحات ۷۸-۰
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